Blog entry by hydrocodone info
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Hydrocodone is a moderately potent, semi synthetic, orally available opioid, which in acetaminophen combination is widely recommended by healthcare experts for treatment of chronic or acute pain. At the same time, it is used in combination with anticholinergics or antihistamines to treat cough. The medicine by itself has actually not been associated to serum enzyme increase during therapy or to medically evident liver injury. However, combination with acetaminophen has in fact been linked to several acute liver failure cases due to unintentional acetaminophen overdose.
It is a derivative of thebaine or codeine, natural alkaloids deduced from resin of papaver somniferum. Usually, hydrocodone is well absorbed orally. It has mild opiate activity, acting a protagonist of u opiate receptor. For ameliorating moderate to severe pain, combination of acetaminophen with hydrocodone has proved to be very effective. The medication is widely prescribed for temporary and chronic pain management. Combination of this drug with acetaminophen helps to preclude its recreational use. The medicine has been in extensive use shortly after its first synthesis in the 1930’s. In the year 1998, it was formally approved by U.S. Food and Drug Administration (FDA) for use in tandem with acetaminophen.
Current uses are meant for treatment of mild to severe pain and distress (combinations with ibuprofen and acetaminophen) or alleviation of upper respiratory tract disease (combined with homatropine or chlorpheniramine) and cough. Currently, it is among the most commonly recommended drugs in medical field. It is available in different formulations, such as syrup, capsules and tablets, combined with other anticholinergics, analgesics in potencies of 2.5mg, 5mg, 7.5mg, and 10mg.
Patients can also get generic versions. Usually, the recommended doses are consumed every 5-6 hours. The acetaminophen dose in hydrocodone combinations differs from 300-1000mg per pill. Nevertheless, the FDA has advised that doctors not use opiate combination with acetaminophen concentration of more than 320mg per unit dosage.
If this drug is mistreated or abused, it will cause harmful effects, addiction and withdrawal symptoms. Some of the negative effects are respiratory depression, sedation, euphoria, mental clouding, constipation, agitation, abdominal bloating, diarrhea, dizziness, headache and queasiness. Long term use could be followed by moderate to severe withdrawal symptoms. It is a controlled drug and has been categorized under Schedule III, pointing that it has therapeutic usefulness. Nonetheless, it also has potential for psychological and physical abuse and dependence. Therefore, to forefend detrimental effects or abuse, take the dosages according to doctor’s guidelines and instructions.