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Percocet contains a combination of acetaminophen and oxycodone. Oxycodone is an opioid pain medication. An opioid is sometimes called a narcotic. Acetaminophen is a less potent pain reliever that increases the effects of oxycodonePercocet is used to relieve moderate to severe pain. Due of the risks

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Percocet exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. Assess each patient’s risk prior to prescribing Percocet, and monitor all patients regularly for the development of these behaviors and conditions

Life-Threatening Respiratory Depression

Serious, life-threatening, or fatal respiratory depression may occur with use of Percocet. Monitor for respiratory depression, especially during initiation of Percocet or following a dose increase 

Accidental Ingestion

Accidental ingestion of Percocet, especially by children, can result in a fatal overdose of Percocet Neonatal Opioid Withdrawal Syndrome

Prolonged use of Percocet during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts. If opioid use is required for a prolonged period in a pregnant woman, advise the patient of the risk of neonatal opioid withdrawal syndrome and ensure that appropriate treatment will be available 

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Cytochrome P450 3A4 Interaction

The concomitant use of Percocet with all cytochrome P450 3A4 inhibitors may result in an increase in oxycodone plasma concentrations, which could increase or prolong adverse reactions and may cause potentially fatal respiratory depression. In addition, discontinuation of a concomitantly used cytochrome P450 3A4 inducer may result in an increase in oxycodone plasma concentration. Monitor patients receiving Percocet and any CYP3A4 inhibitor or inducer PHARMACOLOGYWARNINGSPRECAUTIONS; Drug Interactions 


Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death. Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed 4000 mg per day, and often involve more than one acetaminophen-containing product.

Risks From Concomitant Use With Benzodiazepines Or Other CNS Depressants

Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death

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